SynDocDis: A Metadata-Driven Framework for Generating Synthetic Physician Discussions Using Large Language Models

arXiv:2604.08555v1 Announce Type: new
Abstract: Physician-physician discussions of patient cases represent a rich source of clinical knowledge and reasoning that could feed AI agents to enrich and even participate in subsequent interactions. However, privacy regulations and ethical considerations severely restrict access to such data. While synthetic data generation using Large Language Models offers a promising alternative, existing approaches primarily focus on patient-physician interactions or structured medical records, leaving a significant gap in physician-to-physician communication synthesis. We present SynDocDis, a novel framework that combines structured prompting techniques with privacy-preserving de-identified case metadata to generate clinically accurate physician-to-physician dialogues. Evaluation by five practicing physicians in nine oncology and hepatology scenarios demonstrated exceptional communication effectiveness (mean 4.4/5) and strong medical content quality (mean 4.1/5), with substantial interrater reliability (kappa = 0.70, 95% CI: 0.67-0.73). The framework achieved 91% clinical relevance ratings while maintaining doctors’ and patients’ privacy. These results place SynDocDis as a promising framework for advancing medical AI research ethically and responsibly through privacy-compliant synthetic physician dialogue generation with direct applications in medical education and clinical decision support.