RNNet-MST: A ResNet-50 with Multi-Scale Transformer Blocks for Pulmonary Nodule Classification and Attention-Based Localization on Chest X-Ray Images

Background/Objectives: Lung cancer survival depends on early detection; however, in the Philippines, high radiologist workloads and the anatomical complexity of chest X-rays (CXRs) contribute to missed pulmonary nodules and false-negative diagnoses. This study aims to develop an enhanced deep learning model to improve nodule classification and localization sensitivity. Methods: We propose RNNet-MST, an extension of ResNet-50 that incorporates Multi-Scale Transformer blocks for global context modeling and a custom spatial attention mechanism for attention-based weak localization of disease-relevant regions. The model was trained and evaluated on the NODE21 chest X-ray dataset and compared with a baseline ResNet-50 using classification metrics, with attention maps used for weak localization analysis. Results: RNNet-MST demonstrated improved performance across evaluated metrics relative to the baseline model. Nodule Recall increased from 86.18% to 93.09% (+6.91%), reducing false negatives. Test Accuracy reached 95.16% (+0.51%), and the Nodule F1-Score improved to 91.40% (+1.50%), indicating better detection of small and subtle nodules. Conclusions: The integration of multi-scale transformer features improved classification sensitivity, while the attention mechanism provided weak localization cues that aligned more closely with annotated nodule regions than the baseline. RNNet-MST shows potential as a diagnostic support tool, warranting further validation on larger and more diverse clinical datasets to reduce perceptual errors and facilitate early lung cancer detection in resource-constrained settings.