First time NeurIPS. How different is it from low-ranked conferences? [D]

I’m a PhD student and already published papers in A/B ranked paper (10+). My field of work never allowed me to work on something really exciting and a core A* conference. But finally after years I think I have work worthy of some discussion at the top venue.

I’m referring to papers (my field and top papers) from previous editions and I notice that there’s a big difference on how people write, how they put their message on table and also it is too theoretical sometimes.

Are there any golden rules people follow who frequently get into these conferences? Should I be soft while making novelty claims?

Also those who moved from submitting to niche-conferences to NeurIPS/ICML/CVPR, did you change your approach?

My field is imaging in healthcare.