arXiv:2508.17090v2 Announce Type: replace Abstract: Ecological Momentary Assessment (EMA) studies enable the collection of high-frequency self-reports of suicidal thoughts and behaviors (STBs) via smartphones. Latent stochastic differential equations (SDE) are a promising model class for EMA data, as it is irregularly sampled, noisy, and partially observed. But SDE-based models suffer from two key limitations. (a) These models often violate domain constraints, undermining scientific validity and clinical trust of the model. (b) Training is numerically unstable without ad-hoc fixes […]

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A fun thing about recording a podcast with a professional like Lenny Rachitsky is that his team know how to slice the resulting video up into TikTok-sized short form vertical videos. Here’s one he shared on Twitter today which ended up attracting over 1.1m views! That was 48 seconds. Our full conversation lasted 1 hour 40 minutes. Tags: ai-ethics, coding-agents, agentic-engineering, generative-ai, podcast-appearances, ai, llms, cognitive-debt

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arXiv:2603.14575v2 Announce Type: replace-cross Abstract: Evolve-based agent such as AlphaEvolve is one of the notable successes in using Large Language Models (LLMs) to build AI Scientists. These agents tackle open-ended scientific problems by iteratively improving and evolving programs, leveraging the prior knowledge and reasoning capabilities of LLMs. Despite the success, existing evolve-based agents lack targeted guidance for evolution and effective mechanisms for organizing and utilizing knowledge acquired from past evolutionary experience. Consequently, they suffer from decreasing evolution efficiency […]

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Van der Waals (vdW) interactions are essential for describing molecules and materials, from drug design and catalysis to battery applications. These omnipresent interactions must also be accurately included in machine-learned force fields. The many-body dispersion (MBD) method stands out as one of the most accurate and transferable approaches to capture vdW interactions, requiring only atomic $C_6$ coefficients and polarizabilities as input. We present MBD-ML, a pretrained message passing neural network that predicts these atomic properties directly from atomic […]

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Humanity’s growing interconnection isn’t a social accident, says Teilhard, but evolution becoming self-aware. If life is now reflecting on—and reinventing—itself, then watching human creativity may reveal how new biological forms once emerged. He asks whether “invention,” not just chance and selection, has always nudged life toward greater complexity. In a universe drifting toward the improbable, he wonders: when did consciousness begin steering evolution?

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We study transfer learning for contextual joint assortment-pricing under a multinomial logit choice model with bandit feedback. A seller operates across multiple related markets and observes only posted prices and realized purchases. While data from source markets can accelerate learning in a target market, cross-market differences in customer preferences may introduce systematic bias if pooled indiscriminately. We model heterogeneity through a structured utility shift, where markets share a common contextual utility structure but differ along a sparse set […]

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arXiv:2604.01413v1 Announce Type: new Abstract: Large Language Models (LLMs) increasingly rely on multi-turn reasoning and interaction, such as adaptive retrieval-augmented generation (RAG) and ReAct-style agents, to answer difficult questions. These methods improve accuracy by iteratively retrieving information, reasoning, or acting, but introduce a key challenge: textbf{When should the model stop?} Existing approaches rely on heuristic stopping rules or fixed turn budgets and provide no formal guarantees that the final prediction still contains the correct answer. This limitation is […]

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A 2022 LessWrong post on orexin and the quest for more waking hours argues that orexin agonists could safely reduce human sleep needs, pointing to short-sleeper gene mutations that increase orexin production and to cavefish that evolved heightened orexin sensitivity alongside an 80% reduction in sleep. Several commenters discussed clinical trials, embryo selection, and the evolutionary puzzle of why short-sleeper genes haven’t spread. I thought the whole approach was backwards, and left a comment: Orexin is a signal […]

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arXiv:2602.18581v1 Announce Type: new Abstract: Despite their apparent diversity, modern machine learning methods can be reduced to a remarkably simple core principle: learning is achieved by continuously optimizing parameters to minimize or maximize a scalar objective function. This paradigm has been extraordinarily successful for well-defined tasks where goals are fixed and evaluation criteria are explicit. However, if artificial systems are to move toward true autonomy-operating over long horizons and across evolving contexts-objectives may become ill-defined, shifting, or entirely […]

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