SAGE: Agentic Framework for Interpretable and Clinically Translatable Computational Pathology Biomarker Discovery
arXiv:2602.00953v1 Announce Type: new Abstract: Despite significant progress in computational pathology, many AI models remain black-box and difficult to interpret, posing a major barrier to clinical adoption due to limited transparency and explainability. This has motivated continued interest in engineered image-based biomarkers, which offer greater interpretability but are often proposed based on anecdotal evidence or fragmented prior literature rather than systematic biological validation. We introduce SAGE (Structured Agentic system for hypothesis Generation and Evaluation), an agentic AI system […]