A General Framework for Joint Multi-State Models
arXiv:2510.07128v4 Announce Type: replace-cross Abstract: Conventional joint modeling approaches generally characterize the relationship between longitudinal biomarkers and discrete event occurrences within terminal, recurring or competing risk settings, thereby offering a limited representation of complex, multi-state trajectories. We propose a general multi-state joint modeling framework that unifies longitudinal biomarker dynamics with multi-state time-to-event processes defined on arbitrary directed graphs. The proposed framework also accomodates nonlinear longitudinal submodels and scalable inference via stochastic gradient descent. This formulation encompasses both Markovian […]