Learning Glioblastoma Tumor Heterogeneity Using Brain Inspired Topological Neural Networks
arXiv:2602.11234v1 Announce Type: new Abstract: Accurate prognosis for Glioblastoma (GBM) using deep learning (DL) is hindered by extreme spatial and structural heterogeneity. Moreover, inconsistent MRI acquisition protocols across institutions hinder generalizability of models. Conventional transformer and DL pipelines often fail to capture the multi-scale morphological diversity such as fragmented necrotic cores, infiltrating margins, and disjoint enhancing components leading to scanner-specific artifacts and poor cross-site prognosis. We propose TopoGBM, a learning framework designed to capture heterogeneity-preserved, scanner-robust representations from […]