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Reinforcement learning has shown promise for automating power-grid operation tasks such as topology control and congestion management. However, its deployment in real-world power systems remains limited by strict safety requirements, brittleness under rare disturbances, and poor generalization to unseen grid topologies. In safety-critical infrastructure, catastrophic failures cannot be tolerated, and learning-based controllers must operate within hard physical constraints. This paper proposes a safety-constrained hierarchical control framework for power-grid operation that explicitly decouples long-horizon decision-making from real-time feasibility enforcement. […]

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In recent years, large language models (LLMs) have become indispensable assistants for software engineers and knowledge workers. Nimbus Therapeutics enlisted us at Amazon’s Generative AI Innovation Center and Artificial General Intelligence (AGI) organization to investigate whether it’s possible to make equally capable assistants for medicinal chemists discovering new drugs. Such an agent could significantly speed up drug discovery, potentially saving lives. AI in drug discovery has traditionally involved models called graph neural networks, or GNNs. GNNs are the […]

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Functional magnetic resonance imaging (fMRI) is widely used for studying and diagnosing brain disorders, with functional connectivity (FC) matrices providing powerful representations of large-scale neural interactions. However, existing diagnostic models are trained either on a single site or under full multi-site access, making them unsuitable for real-world scenarios where clinical data arrive sequentially from different institutions. This results in limited generalization and severe catastrophic forgetting. This paper presents the first continual learning framework specifically designed for fMRI-based diagnosis […]

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I think we will see some people employed (though perhaps not explicitly) as meat shields: people who are accountable for ML systems under their supervision. The accountability may be purely internal, as when Meta hires human beings to review the decisions of automated moderation systems. It may be external, as when lawyers are penalized for submitting LLM lies to the court. It may involve formalized responsibility, like a Data Protection Officer. It may be convenient for a company […]

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Accurate methane sorption prediction across heterogeneous coal ranks requires models that combine thermodynamic consistency, efficient knowledge transfer across data-scarce geological systems, and calibrated uncertainty estimates, capabilities that are rarely addressed together in existing frameworks. We present a physics-informed transfer learning framework that adapts a hydrogen sorption PINN to methane sorption prediction via Elastic Weight Consolidation, coal-specific feature engineering, and a three-phase curriculum that progressively balances transfer preservation with thermodynamic fine-tuning. Trained on 993 equilibrium measurements from 114 independent […]

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