February 2026

arXiv:2602.00956v1 Announce Type: new Abstract: Early and accurate diagnosis of Alzheimer’s disease (AD) remains a critical challenge in neuroimaging-based clinical decision support systems. In this work, we propose a novel hybrid deep learning framework that integrates Topological Data Analysis (TDA) with a DenseNet121 backbone for four-class Alzheimer’s disease classification using structural MRI data from the OASIS dataset. TDA is employed to capture complementary topological characteristics of brain structures that are often overlooked by conventional neural networks, while DenseNet121 […]

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arXiv:2602.00954v1 Announce Type: new Abstract: Preference optimization methods such as DPO align large language models (LLMs) using paired comparisons, but their effectiveness can be highly sensitive to the quality and difficulty of preference pairs. A common heuristic treats small-margin (ambiguous) pairs as noisy and filters them out. In this paper, we revisit this assumption and show that pair difficulty interacts strongly with the optimization objective: when trained with preference-based losses, difficult pairs can destabilize training and harm alignment, […]

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arXiv:2602.00953v1 Announce Type: new Abstract: Despite significant progress in computational pathology, many AI models remain black-box and difficult to interpret, posing a major barrier to clinical adoption due to limited transparency and explainability. This has motivated continued interest in engineered image-based biomarkers, which offer greater interpretability but are often proposed based on anecdotal evidence or fragmented prior literature rather than systematic biological validation. We introduce SAGE (Structured Agentic system for hypothesis Generation and Evaluation), an agentic AI system […]

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arXiv:2602.00952v1 Announce Type: new Abstract: The trade-off between labeled data availability and downstream accuracy remains a central challenge in fine-tuning large language models (LLMs). We propose a principled framework for emph{budget-aware supervised fine-tuning} by casting LLM adaptation as a contextual Stackelberg game. In our formulation, the learner (leader) commits to a scoring policy and a label-querying strategy, while an adaptive environment (follower) selects challenging supervised alternatives in response. To explicitly address label efficiency, we incorporate a finite supervision […]

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arXiv:2602.00951v1 Announce Type: new Abstract: We introduce online Hierarchical Task Network (HTN) agents whose behaviors are governed by a set of built-in directives D. Like other agents that are capable of rebellion (i.e., {it intelligent disobedience}), our agents will, under some conditions, not perform a user-assigned task and instead act in ways that do not meet a user’s expectations. Our work combines three concepts: HTN planning, online planning, and the directives D, which must be considered when performing […]

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arXiv:2602.00950v1 Announce Type: new Abstract: Large language models are increasingly used for mental health support, yet their conversational coherence alone does not ensure clinical appropriateness. Existing general-purpose safeguards often fail to distinguish between therapeutic disclosures and genuine clinical crises, leading to safety failures. To address this gap, we introduce a clinically grounded risk taxonomy, developed in collaboration with PhD-level psychologists, that identifies actionable harm (e.g., self-harm and harm to others) while preserving space for safe, non-crisis therapeutic content. […]

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arXiv:2602.00949v1 Announce Type: new Abstract: Chimeric antigen receptor (CAR)-T and NK cell immunotherapies have transformed cancer treatment, and recent studies suggest that the quality of the CAR-T/NK cell immunological synapse (IS) may serve as a functional biomarker for predicting therapeutic efficacy. Accurate detection and segmentation of CAR-T/NK IS structures using artificial neural networks (ANNs) can greatly increase the speed and reliability of IS quantification. However, a persistent challenge is the limited size of annotated microscopy datasets, which restricts […]

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arXiv:2602.00947v1 Announce Type: new Abstract: Chat has become the default interface for AI-assisted data analysis. For multi-step, state-dependent analytical tasks, this is a mistake. Building on Woods (1984) Keyhole Effect, the cognitive cost of viewing large information spaces through narrow viewports, I show that chat interfaces systematically degrade analytical performance through five mechanisms: (1) constant content displacement defeats hippocampal spatial memory systems; (2) hidden state variables exceed working memory capacity (approximately 4 chunks under load); (3) forced verbalization […]

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arXiv:2602.00946v1 Announce Type: new Abstract: Vision-Language Models (VLMs) are expensive because the LLM processes hundreds of largely redundant visual tokens. Existing token reduction methods typically exploit textit{either} vision-encoder saliency (broad but query-agnostic) textit{or} LLM cross-attention (query-aware but sparse and costly). We show that neither signal alone is sufficient: fusing them consistently improves performance compared to unimodal visual token selection (ranking). However, making such fusion practical is non-trivial: cross-modal saliency is usually only available emph{inside} the LLM (too late […]

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arXiv:2602.00945v1 Announce Type: new Abstract: LLMs are multilingual by training, yet their lingua franca is often English, reflecting English language dominance in pretraining. Other languages remain in parametric memory but are systematically suppressed. We argue that language defaultness is governed by a sparse, low-rank control circuit, language neurons, that can be mechanistically isolated and safely steered. We introduce Neural FOXP2, that makes a chosen language (Hindi or Spanish) primary in a model by steering language-specific neurons. Neural FOXP2 […]

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