Disentangling Shared and Target-Enriched Topics via Background-Contrastive Non-negative Matrix Factorization
arXiv:2602.22387v1 Announce Type: new Abstract: Biological signals of interest in high-dimensional data are often masked by dominant variation shared across conditions. This variation, arising from baseline biological structure or technical effects, can prevent standard dimensionality reduction methods from resolving condition-specific structure. The challenge is that these confounding topics are often unknown and mixed with biological signals. Existing background correction methods are either unscalable to high dimensions or not interpretable. We introduce background contrastive Non-negative Matrix Factorization (model), which […]