Predicting Multi-Drug Resistance in Bacterial Isolates Through Performance Comparison and LIME-based Interpretation of Classification Models
arXiv:2602.22400v1 Announce Type: new Abstract: The rise of Antimicrobial Resistance, particularly Multi-Drug Resistance (MDR), presents a critical challenge for clinical decision-making due to limited treatment options and delays in conventional susceptibility testing. This study proposes an interpretable machine learning framework to predict MDR in bacterial isolates using clinical features and antibiotic susceptibility patterns. Five classification models were evaluated, including Logistic Regression, Random Forest, AdaBoost, XGBoost, and LightGBM. The models were trained on a curated dataset of 9,714 isolates, […]