The Challenge of BWAS: Unknown Unknowns in Feature Space and Variance

The paper by Marek et al (Reproducible brain-wide association studies require thousands of individuals, Nature, 602, 7902, pp 654-660, 2022) came out recently, and caused a bit of a stir in the field for a couple of reasons: First, the title, while an accurate description of the findings of the paper, is bold and lacking just enough qualifiers to quell immediate questions. “Does this imply that fMRI or other measures used in BWAS are lacking intrinsic sensitivity?” “Is […]

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